ArticleJournal of pharmacopuncture2026
Protocol for a Radial Pulse-Based Vascular Age Index Integrated with Traditional Korean Medicine Pulse Diagnosis.
Article in Journal of pharmacopuncture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Vascular aging, a central determinant of cardiovascular risk, is commonly assessed by pulse wave velocity (PWV)-based indices such as carotid-femoral PWV (cfPWV). However, these methods are not always feasible in routine or integrative clinical settings, requiring specialized equipment. Radial artery pulse wave analysis has emerged as a non-invasive alternative for estimating vascular age, while traditional Korean medicine (TKM) pulse diagnosis provides a qualitative assessment of vascular and systemic conditions. Despite the conceptual overlap, integration of modern vascular metrics with TKM pulse diagnosis remains limited. This study aims to develop and validate a radial pulse-based vascular age index (RP-VAI) and investigate its association with conventional vascular aging markers and TKM pulse characteristics. Methods: A prospective observational study will be conducted, with all measurements performed in an examination room at a Korean medicine hospital. Radial pulse signals will be acquired bilaterally at the wrist, including traditional palpation sites (chon, gwan, and cheok). Signal processing will extract time-domain, morphological, and spectral features. A vascular age prediction model will be developed using multiple linear regression and machine learning. TKM pulse diagnosis will be independently assessed by trained practitioners. The associations between RP-VAI, PWV-based indices, and TKM pulse features will be analyzed. Expected Outcomes: The study is expected to establish a novel integrative vascular aging index that bridges biomedical signal analysis and traditional pulse diagnosis, enabling a more comprehensive assessment of aging-related vascular changes. Conclusion: This study will establish and validate the RP-VAI, an integrative index, which may serve as an accessible tool for assessing vascular aging by bridging traditional pulse diagnosis with modern biomedical analysis.
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