ReviewPolymer science & technology (Washington, D.C.)2026
Polysaccharide-Based Encapsulation of Microbes for Enhanced Microbial Therapy.
Review in Polymer science & technology (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of living microorganisms as therapeutics holds considerable potential but faces dual challenges of overcoming physiological barriers and host immune clearance. This review summarizes innovative encapsulation strategies using polysaccharide polymers to address these challenges. It begins by introducing encapsulation-compatible microbial taxa and the properties of major polysaccharide classes, including cationic, anionic, gel-forming, and neutral. Then, the review elaborates on two core functionalization strategies, namely non-covalent and covalent modification. It further analyzes key functions provided by polysaccharide encapsulation, such as protective effects, immunomodulation, targeted delivery, and synergistic therapy. Representative applications in treating tumors, bacterial infections, and inflammatory bowel diseases are summarized. Lastly, current challenges and future directions are discussed to guide the development of next-generation safe and effective microbial living therapeutics. This review positions polysaccharide-based encapsulation as a versatile platform for augmenting the therapeutic functionality of living microbial therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.