ArticlePolymer science & technology (Washington, D.C.)2026
pH-Ultrasensitive Polyester Nanoprobe for High-Contrast Tumor Imaging with Superior Biocompatibility.
Article in Polymer science & technology (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transistor-like nanoprobes enable highly sensitive detection of dysregulated pH, showing great promise for tumor imaging. Their pH sensitivity arises from protonation of ionizable tertiary amines on the polymer side chains, which can increase the interaction with negatively charged cell membranes, raising risks of cytotoxicity and biosafety. Herein, we present a platform of pH-ultrasensitive polyester nanoprobes (pUPNs) that exhibit minimal toxicity upon activation and feature tunable pH responsiveness. The pUPNs self-assemble from pH-responsive polyesters, whose backbones possess high steric hindrance to minimize interactions with cell membranes. Their side chains are covalently grafted with ionizable tertiary amines and self-quenched fluorescent dyes to finely adjust the sensitivity to subtle pH variations. Interestingly, pUPN with the lowest transition pH exhibits the best tumor imaging contrast. These pUPNs demonstrated excellent biocompatibility after intravenous administration with no detectable hepatic or renal toxicity. This study presents a design platform for pH-ultrasensitive nanoprobes with excellent sensitivity and biocompatibility through increased steric hindrance in the polymer backbone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.