ArticleFrontiers in systems neuroscience2026
The volatile anesthetic isoflurane causes global suppression of neuronal activity, disrupting hub neuron function in
Article in Frontiers in systems neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Volatile anesthetics, such as isoflurane, generate a state of unconsciousness and analgesia across the animal kingdom and are widely used in clinical settings. Yet, anesthetic mechanisms are poorly understood: the volatile anesthetics are so profligate in their potential effects that it has proven difficult to determine which actions are most causal at the systems level. Methods: To test if specific cellular targets mediate the anesthetic effect across a complete, intact nervous system, we imaged neuron activity in the Results: However, rather than dramatic effects on any particular neuronal class, we measured uniform suppression of both neuron activity and connectivity with increasing isoflurane across the nervous system. We find the degree of activity suppression to be proportional to the baseline activity of the neuron in the awake state. Within this context, highly connected neurons, specifically neurons with high in-degree connectivity, are inherently active and display large activity suppression. These include hub interneurons within the Discussion: Exploiting the small size, simplicity and optical accessibility of
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