Evidence map›Paper›PMID 42368381›Full record

ArticleNeuro-oncology advances

Needle-track metastasis in diffuse intrinsic pontine glioma: Need for a standardized surgical strategy?

Gunther Nussbaumer, Olga Nigro, Anke Barnbrock, Martin Benesch, Veronica Biassoni, Hans Christoph Bock, Andrea Carai, Anna Cavallo, Silvia Chiesa, Tommaso Giandini and 36 more

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Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Gunther NussbaumerDivision of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.ORCID https://orcid.org/0000-0003-0397-935X
Olga NigroPediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID https://orcid.org/0000-0002-1030-2809
Anke BarnbrockDepartment of Pediatrics, Goethe-University Frankfurt, Frankfurt, Germany.
Martin BeneschDivision of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.
Veronica BiassoniPediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID https://orcid.org/0000-0003-1486-1736
Hans Christoph BockDivision of Pediatric Neurosurgery, Department of Neurosurgery, University Medical Center Göttingen, Goettingen, Germany.
Andrea CaraiNeurosurgery Unit, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.ORCID https://orcid.org/0000-0002-5203-7855
Anna CavalloS.C. Fisica Sanitaria, Medical Physics Unit, Department of Diagnostic Imaging and Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Silvia ChiesaUOC di Radioterapia Oncologica, Dipartimento Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.
Tommaso GiandiniS.C. Fisica Sanitaria, Medical Physics Unit, Department of Diagnostic Imaging and Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Giovanna Stefania ColafatiOncological Neuroradiology and Advanced Diagnostics Unit, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.
Lucia De MartinoU.O.S.D. Neurooncologia, Ospedale Santobono-A.O.R.N. Santobono-Pausilipon, Napoli, Italy.
Martin DemmertDepartment of Pediatric and Adolescent Medicine, Pediatric Hematology and Oncology, University Hospital Schleswig Holstein, Lübeck, Germany.
Valentina di RuscioNeuro-Oncology Unit, Hematology/Oncology, Cell Therapy, Gene Therapies and Hematopoietic Transplant, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Jeanne-Marie FrankeDivision of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.
Lea L FrikerInstitute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.
Gerrit H GielenInstitute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.
Marion HoffmannDivision of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.
Karolina JablonskaDepartment of Radiation Oncology, CyberKnife and Radiation Therapy, Centre for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Axel KarowPediatric Oncology and Hematology, Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.
Michael KarremannDepartment of Pediatric and Adolescent Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0000-0002-9961-4752
Kornelius KerlDepartment of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.ORCID https://orcid.org/0000-0002-5676-8102
Friederike Knerlich-LukoschusDivision of Pediatric Neurosurgery, Department of Neurosurgery, University Medical Center Göttingen, Goettingen, Germany.
Christof M KrammDivision of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.
Mechthild KrauseDepartment of Radiotherapy and Radiation Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Sebastian MakockiDepartment of Radiotherapy and Radiation Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Angela MastronuzziNeuro-Oncology Unit, Hematology/Oncology, Cell Therapy, Gene Therapies and Hematopoietic Transplant, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.ORCID https://orcid.org/0000-0002-4408-2373
Maura MassiminoPediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID https://orcid.org/0000-0002-5506-2001
Andrés Morales La MadridPediatric Neuro-Oncology Unit, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu, Barcelona, Spain.
Emilia PecoriPediatric Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID https://orcid.org/0000-0002-1962-8143
Thomas PerweinDivision of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.ORCID https://orcid.org/0000-0001-6952-1339
Torsten PietschInstitute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.
Dirk RadesDepartment of Radiation Oncology, University of Luebeck, Luebeck, Germany.
Claus RödelDepartment of Radiotherapy, University of Frankfurt, Frankfurt, Germany.
Vicente Santa-Maria LopezPediatric Neuro-Oncology Unit, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Deu, Barcelona, Spain.ORCID https://orcid.org/0000-0001-8450-0480
Elisabetta SchiavelloPediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.ORCID https://orcid.org/0000-0002-8049-7445
Rudolph SchwarzDepartment for Radiotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sergiu ScobioalaDepartment of Radiation Oncology, Münster University Hospital, Münster, Germany.
Thorsten SimonDepartment of Pediatric Hematology and Oncology, University of Cologne, Cologne, Germany.
Dorothee C SpilleDepartment of Neurosurgery, University Hospital Münster, Münster, Germany.
Ulrich-Wilhelm ThomalePediatric Neurosurgery, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Arianna TrovòPediatric Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Sabina VennariniPediatric Radiotherapy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.ORCID https://orcid.org/0000-0002-8712-8781
André O von BuerenDepartment of Pediatrics, Gynecology and Obstetrics, Division of Pediatric Hematology and Oncology, University Hospital of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0003-4197-6264
Brigitte BisonDiagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.
Chiara ValentiniDepartment of Radiotherapy and Radiation Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diffuse intrinsic pontine glioma (DIPG) remains uniformly lethal. Stereotactic biopsy confirms the diagnosis and enables molecular profiling. Metastasis along the biopsy track (BTM) has been reported only anecdotally; its prevalence, clinical relevance, and implications for treatment remain unclear. Methods: A multicenter retrospective study in patients with confirmed DIPG and BTM was conducted based on central neuroradiologic review. Radiotherapy schedules were re-assessed to evaluate the feasibility of upfront biopsy track irradiation. Results: Ten children met inclusion criteria (median age 6.8 years). Biopsy route was supratentorial in six and infratentorial in four children, and side-cutting needles were used predominantly. Conclusions: Needle track metastasis is a rare progression pattern in stereotactic biopsied DIPG. Upfront irradiation of the biopsy track may represent a strategy to mitigate the potential risk of BTM. From a dosimetric perspective, an infratentorial approach may therefore be considered, as it was associated with only marginally increased radiation exposure.

Indexed as

biopsy track metastasisdiffuse intrinsic pontine gliomadiffuse midline gliomaDMG K27MH3 K27-alteredradiotherapy

Identifiers

PMID42368381
PMCPMC13302791

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