Evidence map›Paper›PMID 42368361›Full record

ArticleClinical case reports2026

Phenobarbital-Induced Toxic Epidermal Necrolysis: A Case Report.

Biniyam Tedla Mamo, Solomon Getnet Meshesha, Zelalem Aysheshim Andualem, Kisi Chemeda Gutema, Abenezer Abrham Anito, Mehiret Maru Haile, Hilina Worku Jembere, Asnakech Alemu, Teshita Shute

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Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Biniyam Tedla MamoEthiopian Food and Drug Administration Addis Ababa Ethiopia.ORCID https://orcid.org/0009-0005-5586-2964
Solomon Getnet MesheshaEthiopian Food and Drug Administration Addis Ababa Ethiopia.ORCID https://orcid.org/0000-0002-8198-2848
Zelalem Aysheshim AndualemEthiopian Food and Drug Administration Addis Ababa Ethiopia.
Kisi Chemeda GutemaJimma University, Institute of Health Jimma Ethiopia.
Abenezer Abrham AnitoEthiopian Food and Drug Administration Addis Ababa Ethiopia.
Mehiret Maru HaileEthiopian Food and Drug Administration Addis Ababa Ethiopia.
Hilina Worku JembereWorld Health Organization, Ethiopia Office Addis Ababa Ethiopia.
Asnakech AlemuEthiopian Food and Drug Administration Addis Ababa Ethiopia.
Teshita ShuteEthiopian Food and Drug Administration Addis Ababa Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adverse drug reactions (ADRs) can lead to severe consequences and increased morbidity and mortality rates. Phenobarbital is one of the most common anti-epileptic drugs that has numerous adverse drug reactions, including toxic epidermal necrolysis. The event is rare and a medical emergency. A six-year-old female epileptic child with phenobarbital-induced toxic epidermal necrolysis was referred for the management of diffuse exfoliative lesions involving her eyes and buccal mucosa. Associated with the skin lesions, the patient reported high-grade fever, reddish eye discoloration, dysphagia and dry cough. The exfoliative skin lesion involved 90% of her total body surface area. The patient was managed with withdrawal of phenobarbital, IV antibiotics, systemic corticosteroid, twice daily wound care, analgesic, and nutritional support. Early recognition, discontinuation of offending medications and prompt intervention are crucial to mitigate harm. Raising awareness about ADRs and their management is vital for enhancing patient safety and outcomes.

Indexed as

adverse drug reactionpharmacovigilancephenobarbitalsevere cutaneous adverse reactiontoxic epidermal necrolysis

Identifiers

PMID42368361
PMCPMC13307204

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