ArticleFrontiers in pediatrics2026
Efficacy and safety of sini powder combined with Xiaoxianxiong decoction for adolescent depression with liver qi stagnation and phlegm-heat obstruction syndrome: a randomized controlled trial.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To assess efficacy and safety of Sini San combined with Xiaoxianxiong Tang as add-on therapy for adolescents (12-18 years) with liver qi stagnation and phlegm-heat depression, and to provide preliminary evidence for TCM syndrome-based treatment. Methods: Sixty adolescents (12-18 years) with moderate depression (DSM-5 criteria) meeting TCM syndrome standards were recruited from Youxian Branch of Mianyang Third Hospital (Jan 2024-Dec 2025). Sample size was calculated via G*Power 3.1 (effect size=0.8, Results: Baseline characteristics were comparable between groups (all Conclusion: As an add-on therapy to psychological counseling, Sini San combined with Xiaoxianxiong Decoction shows preliminary short-term efficacy in alleviating depressive symptoms and improving quality of life in adolescents with target TCM syndrome, with favorable short-term safety. Due to small sample size, single-center design, lack of double-blinding and placebo control, the findings are hypothesis-generating and cannot support broad clinical promotion.
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