Evidence map›Paper›PMID 42368194›Full record

ArticleNeuroprotection (Chichester, England)2026

Bee venom enhances dopaminergic function and behavioral recovery in a murine model of Parkinson's disease.

Silvia Josefina López-Pérez, Marco Antonio Noriega-Ruiz, Alma Karen Lomeli-Lepe

Abstract read
In one paragraph

Article in Neuroprotection (Chichester, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Silvia Josefina López-PérezInstitute of Neurobiology, Department of Cellular and Molecular Biology Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), University of Guadalajara Zapopan Jalisco Mexico.
Marco Antonio Noriega-RuizInstitute of Neurobiology, Department of Cellular and Molecular Biology Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), University of Guadalajara Zapopan Jalisco Mexico.
Alma Karen Lomeli-LepeInstitute of Neurobiology, Department of Cellular and Molecular Biology Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), University of Guadalajara Zapopan Jalisco Mexico.ORCID https://orcid.org/0009-0007-4853-5986

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons, leading to motor dysfunction and cognitive impairment. Although levodopa (l-DOPA)/carbidopa remains the gold standard therapy for PD, its efficacy declines over time, highlighting the need for adjuvant strategies that improve functional outcomes. This study evaluated whether freeze-dried bee venom (BV) enhances the behavioral effects of l-DOPA/carbidopa in a murine model of PD. Methods: Adult male mice (age: 3.0-3.5 months) were randomly assigned using a computer-generated randomization sequence to the following experimental groups: SHAM, animals that were injected with saline in the dorsomedial striatum (STR) ( Results: Compared with 6-OHDA treatment, the combined treatment with BV and l-DOPA/carbidopa significantly improved forelimb motor symmetry ( Conclusion: These findings provide behavioral evidence that BV may serve as a promising adjuvant to l-DOPA/carbidopa, improving both motor and cognitive outcomes in a mouse model of PD and supporting further investigation in studies incorporating histological and molecular endpoints.

Indexed as

bee venomcognitiondopaminergic neuronsmotor activityneuroprotectionParkinson disease

Identifiers

PMID42368194
PMCPMC13306114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.