Interactions and Conformational Plasticity of Human Uncoupling Protein 1 in Response to Small-Molecule Analogues: Insights from Molecular Dynamics Simulations.

Sanket Rathod, Utkarsh A Jagtap, Falguni Pankhania, Ravi Shukla, Atish T Paul

Abstract read

In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sanket RathodLaboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.ORCID https://orcid.org/0000-0002-8037-5974

Utkarsh A JagtapLaboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.

Falguni PankhaniaLaboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.

Ravi ShuklaSchool of Science, RMIT University, Melbourne, VIC 3000, Australia.ORCID https://orcid.org/0000-0002-1537-9637

Atish T PaulLaboratory of Natural Product Chemistry, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.ORCID https://orcid.org/0000-0002-8143-5721

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a multifactorial metabolic disorder associated with excess adiposity and risk of comorbidities. Uncoupling protein 1 (UCP1) is a mitochondrial inner-membrane carrier enriched in brown and beige adipose tissue. UCP1 dissipates the proton motive force to drive nonshivering thermogenesis, making it an attractive target for antiobesity drug discovery. However, the molecular determinants governing small-molecule engagement of UCP1 remain incompletely defined. Here, we applied an integrated

Identifiers

PMID42368086

DOI10.1021/acsomega.6c01124

PMCPMC13295038

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.