Evidence map›Paper›PMID 42368058›Full record

ArticleACS omega2026

Design, Synthesis, and Antimalarial Evaluation of Novel Quinazolin-4(3

Igor José Dos Santos Nascimento, Karla Joane da Silva Menezes, Margarida Cochicho Leonardo, Inês Morais, Carolina Silva Dias Vieira, Sara Silva Pereira, Sofia Cortes, Rui Moreira, Fátima Nogueira, Ricardo Olimpio de Moura

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In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Igor José Dos Santos NascimentoPostgraduate Program of Pharmaceutical Sciences, Pharmacy Department, State University of Paraíba, Campina Grande, Paraíba 58429-500, Brazil.ORCID https://orcid.org/0000-0002-2664-4336
Karla Joane da Silva MenezesGlobal Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (Unl), Rua da Junqueira 100, Lisbon 1349-008, Portugal.
Margarida Cochicho LeonardoGlobal Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (Unl), Rua da Junqueira 100, Lisbon 1349-008, Portugal.
Inês MoraisGlobal Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (Unl), Rua da Junqueira 100, Lisbon 1349-008, Portugal.
Carolina Silva Dias VieiraCatólica Biomedical Research Centre, Católica Medical School, Universidade Católica Portuguesa, Oeiras 2780-156, Portugal.
Sara Silva PereiraCatólica Biomedical Research Centre, Católica Medical School, Universidade Católica Portuguesa, Oeiras 2780-156, Portugal.
Sofia CortesGlobal Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (Unl), Rua da Junqueira 100, Lisbon 1349-008, Portugal.ORCID https://orcid.org/0000-0001-5850-6950
Rui MoreiraResearch Institute for medicines (iMed.ULisboa),Faculty of Pharmacy, Universidade de Lisboa, Lisbon 1649-003, Portugal.
Fátima NogueiraGlobal Health and Tropical Medicine (GHTM), Associate Laboratory in Translation and Innovation Towards Global Health (LA-REAL), Instituto de Higiene e Medicina Tropical (IHMT), Universidade NOVA de Lisboa (Unl), Rua da Junqueira 100, Lisbon 1349-008, Portugal.ORCID https://orcid.org/0000-0003-0313-0778
Ricardo Olimpio de MouraPostgraduate Program of Pharmaceutical Sciences, Pharmacy Department, State University of Paraíba, Campina Grande, Paraíba 58429-500, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malaria is a tropical disease caused by protozoa of the genus Plasmodium and is responsible for several deaths worldwide. Current therapies are limited by the high incidence of adverse effects and the rising prevalence of parasite drug resistance, underscoring the need for research into new chemical scaffolds that can overcome these limitations and for the identification of novel drug targets to advance antimalarial development. In this context, quinazolines show promising potential as new antimalarials. Therefore, in this study, a new series of quinazolin-4-(3

Identifiers

PMID42368058
PMCPMC13294948

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.