Evidence map›Paper›PMID 42368003›Full record

ArticlebioRxiv : the preprint server for biology2026

Filling the Void: Rapid Revascularization via Vasculogenic Assembly in Semi-synthetic Granular Hydrogel Grafts.

Michael M Hu, Despina I Pavlidis, Courtney Lestock, Gonzalo Anyosa-Galvez, Kaley Lollis, Yimeng Zhao, Firaol S Midekssa, Robert N Kent, Ariella Shikanov, Brendon M Baker

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michael M HuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-3979-0196
Despina I PavlidisDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-2156-3561
Courtney LestockDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.
Gonzalo Anyosa-GalvezDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.
Kaley LollisDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.
Yimeng ZhaoDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.
Firaol S MidekssaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0009-0007-2260-1690
Robert N KentDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-1287-6301
Ariella ShikanovDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-0159-6419
Brendon M BakerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-2785-1070

Funding

Angiogenic hydrogel composites for microvascular integration of organoid graftsR01EB030474 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKER, BRENDON M · 2021 to 2024
$1.4M
NIBIB NIH HHS R01 EB030474
6 · The paper itself

Abstract

Rapid revascularization is critical to tissue graft survival, as delayed reperfusion drives tissue ischemia and compromises cell viability and graft function. Although bulk hydrogels have been explored for promoting vessel formation, vascularization remains too slow to prevent ischemic injury to grafted tissues, highlighting the need for biomaterial platforms that accelerate graft revascularization and reperfusion. In this study, we present granular hydrogel composites (GHCs), where interstitial space is filled with fibrin and collagen to provide a vasculogenic matrix environment. GHCs supported the assembly of embedded endothelial cells into interconnected, lumenized networks in vitro which anastomosed with host vasculature and were systemically perfused 7 days after implantation. Careful optimization studies revealed that GHCs formed from covalently interlinked, RGD-functionalized microgels of 115 μm diameter best supported vascular network formation

Indexed as

Graft RevascularizationGranular hydrogelVasculogenesis

Identifiers

PMID42368003
PMCPMC13308006

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.