ArticlebioRxiv : the preprint server for biology2026
Microelectrode arrays enable directional stereo-EEG during kainate-mediated seizures.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Surgical planning for drug-resistant epilepsy often relies on stereo-EEG (sEEG) recordings obtained with cylindrical ring electrodes. Prior modeling studies, including lead-field analysis, suggest that microelectrodes distributed around an sEEG-sized insulating body offer superior source amplification and directional sensitivity that are not available with either a ring design or microelectrodes on micro-structures, e.g. Neuropixel. However, these advantages have not been demonstrated in seizure models. This study evaluated high-density sEEG recordings using directional microelectrode arrays in a kainate-mediated rat model (n=6). Two 64-channel microelectrode arrays were implanted near the hippocampus, and the signals were spatially averaged to emulate virtual ring electrodes for comparison. Device locations were reconstructed and placed in copies of the Waxholm Space Rat Brain Atlas registered to subject-specific MRI scans. In subjects exhibiting seizures (n=4), automated line length detection showed that microelectrode signals identified epileptiform activity sooner and with greater specificity than ring electrodes. In subjects that only seized post-kainate injection (n=3), manual review by a board-certified epileptologist confirmed that microelectrodes provided the earliest onset detection times. Furthermore, the microelectrode arrays' high resolution revealed distinct instances of hyperactivity occurring at similar depths but from different directions - a feature indistinguishable to standard ring electrodes. These results demonstrate that microelectrodes on a large insulating body significantly enhance signal quality and spatial localization. This technology offers a potential advancement over current clinical standards for identifying seizure foci during surgical planning.
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