Evidence map›Paper›PMID 42367980›Full record

ArticlebioRxiv : the preprint server for biology2026

Psychedelics relax predictive processing in the post-acute period by remodeling cortico-cortical feedback circuits.

Chloe L West, Fumiyasu Imai, Georgia Bastos, Molly A Hornick, Lital Rachmany, Annabel Duran, Samen Nadeem, David Ricci, Anna M Rader Groves, Joseph A Wargo and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chloe L WestNeuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA.
Fumiyasu ImaiDepartment of Psychiatry, New York University Grossman School of Medicine, One Park Ave, New York, NY 10016.
Georgia BastosNeuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA.
Molly A HornickEmotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10692.
Lital RachmanyEmotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10692.
Annabel DuranNeuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA.
Samen NadeemNeuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA.
David RicciNeuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA.
Anna M Rader GrovesNeuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA.ORCID 0009-0001-5304-2189
Joseph A WargoNeuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA.
Neil Van LeeuwenDepartment of Philosophy, Florida State University, Dodd Hall, 151, 641 University Way, Tallahassee, FL 32304, USA.
Henry SershenDepartment of Psychiatry, New York University Grossman School of Medicine, One Park Ave, New York, NY 10016.ORCID 0000-0002-7922-2217
K Yaragudri VinodEmotional Brain Institute, Nathan S. Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10692.ORCID 0000-0003-4002-144X
Darcy S PeterkaMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-7351-5820
Jordan P HammNeuroscience Institute, Georgia State University, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA.ORCID 0000-0002-9868-6121

Funding

Circuits for deviance detection in V1R01EY033950 · NEI · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Jordan P Hamm · 2022 to 2026
$2.0M
NEI NIH HHS R01 EY033950
6 · The paper itself

Abstract

Serotonergic psychedelics (e.g., psilocybin, LSD) have potential to treat psychiatric disorders, with therapeutic effects lasting days to weeks after a single dose. Prominent theories suggest that psychedelics have a lasting effect on hierarchical brain circuits, reducing top-down influence on information processing to facilitate an unbiased, bottom-up reassessment of the world, but direct and concrete evidence for such an effect is lacking. Here we directly tested this hypothesis in both humans and mice, assessing predictive processing in the fronto-visual system in the days after a single psychedelic exposure. Individuals who recently (<3 weeks) used 5-HT

Indexed as

5-MeO-DMTanterior cingulate areaLSDmismatch negativityoddballpredictive codingpsilocybinpsychedelicsaccades

Identifiers

PMID42367980
PMCPMC13307955

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.