Evidence map›Paper›PMID 42367963›Full record

ArticlebioRxiv : the preprint server for biology2026

The optical origin of the human skin color 'banana' in CIELAB space.

Maysoon Harunani, Ye Jin Han, Mutian Shen, Blake Sparkman, David Chen, Zohar Nussinov, Leonid Shmuylovich

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maysoon HarunaniDepartment of Biomedical Engineering, Washington University in Saint Louis, MO 63110.
Ye Jin HanDepartment of Physics, Washington University in Saint Louis, MO 63110.
Mutian ShenDepartment of Physics, Washington University in Saint Louis, MO 63110.
Blake SparkmanDepartment of Medicine, Division of Dermatology, Washington University in Saint Louis, MO, 63110.
David ChenDepartment of Medicine, Division of Dermatology, Washington University in Saint Louis, MO, 63110.ORCID 0000-0002-3681-6576
Zohar NussinovDepartment of Physics, Washington University in Saint Louis, MO 63110.
Leonid ShmuylovichDepartment of Biomedical Engineering, Washington University in Saint Louis, MO 63110.ORCID 0000-0001-9210-7873

Funding

Infrared Skin Imaging to Transform Noninvasive Diagnosis and Management of Skin DiseaseDP5OD031872 · OD · WASHINGTON UNIVERSITY · PI SHMUYLOVICH, LEONID · 2021 to 2025
$1.9M
NIH HHS DP5 OD031872
6 · The paper itself

Abstract

Human skin colors occupy a characteristic banana-shaped region in CIE L*a*b* space, but why skin color coordinates are restricted to this region and how they relate to melanin and blood remain incompletely understood. We developed a physics-based framework linking skin chromophore content to colorimeter-derived skin color coordinates using two complementary three-layer light transport models. Across physiologic ranges of epidermal melanosome volume fraction and dermal blood volume fraction, simulated reflectance spectra were converted to CIE L*a*b* coordinates and compared with human skin color measurements from the International Skin Spectra Archive. Physiologic variation in melanin and blood reproduced the observed banana-shaped locus and revealed distinct chromophore-specific trajectories. Iso-melanin trajectories became progressively more linear as melanin increased, whereas iso-blood trajectories retained the curvature of the skin color locus. As melanin increased, perceptible color differences from blood volume changes were reduced, providing a mechanistic explanation for reduced erythema visibility in highly pigmented skin. These relationships were stable across plausible variations in layer thickness and tissue oxygenation and agreed with external validation data. The framework also identified when the Individual Typology Angle is confounded by blood or distorted by dermal melanin. Together, these findings establish a mechanistic optical basis for interpreting colorimeter-derived skin color coordinates.

Indexed as

adding doublingcolorimetryIndividual Typology AngleMonte Carloobjective skin color measurementTissue optics

Identifiers

PMID42367963
PMCPMC13307969

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.