Evidence map›Paper›PMID 42367947›Full record

ArticlebioRxiv : the preprint server for biology2026

Early life Oxytocin treatment Attenuates Seizure Susceptibility in Male, but not Female,

Jasmine Chavez, Julie C Lauterborn, Gary Lynch, Christine M Gall

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jasmine ChavezDepartment of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA.
Julie C LauterbornDepartment of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA.
Gary LynchDepartment of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA.
Christine M GallDepartment of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA.

Funding

Postnatal Oxytocin Treatment and Cognitive Function in FragileXR01HD101642 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI GALL, CHRISTINE M, LYNCH, GARY S · 2021 to 2025
$2.5M
NICHD NIH HHS R01 HD101642
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is the leading inherited cause of intellectual disability, and is frequently accompanied by seizures. Early-life treatment with the hormone oxytocin (OXT) improves social behavior and cognitive function in rodent models of autism with intellectual disability, including FXS, but potential OXT treatment effects on seizure susceptibility have not been evaluated. Here we tested, in both sexes, if intranasal OXT (iOXT) or saline (iSAL) during the second postnatal week reduces audiogenic seizures (AGS) in the

Indexed as

age-dependentaudiogenic seizuresfragile X syndromemousesex differences

Identifiers

PMID42367947
PMCPMC13308197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.