Evidence map›Paper›PMID 42367946›Full record

ArticlebioRxiv : the preprint server for biology2026

Metabolic Gating and the Evolution of Human Cognitive Plasticity: A Comparative Genomic Analysis.

Bryan A Krantz

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Bryan A KrantzDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, U.S.A.ORCID 0000-0002-4911-5824

Funding

Molecular mechanisms of anthrax toxin unfolding and translocationR21AI177237 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI KRANTZ, BRYAN ANDREW · 2025 to 2025
$425k
NIAID NIH HHS R21 AI177237
6 · The paper itself

Abstract

The genetic basis of extreme cognitive plasticity-and its paradoxical overlap with severe neuropsychiatric conditions like schizophrenia-remains one of human evolution's greatest mysteries. We hypothesized that this shared genomic architecture does not represent a collection of broken genes, but rather a high-performance cognitive engine governed by strict metabolic constraints. By integrating population-level data from psychiatric cohorts and highly creative individuals, we identified an evolutionarily conserved "Vanguard Engine." This architecture comprises hyper-tuned voltage-gated calcium channels (

Indexed as

Balancing SelectionBeta-hydroxybutyrateCognitive PlasticityEvolutionary PsychiatryHCAR1 (GPR81)HCAR2 (GPR109A)LactateMetabolic PsychiatryPolygenic ArchitectureSchizophrenia

Identifiers

PMID42367946
PMCPMC13308051

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.