Evidence map›Paper›PMID 42367921›Full record

ArticlebioRxiv : the preprint server for biology2026

Discovery of cell-active small molecule inhibitors of UDP-galactose 4'-epimerase.

Sai Kwan Khal, Noah A Linhart, Shivam Jain, Gilbert Rosario Acevedo, Michael Boyce

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sai Kwan KhalDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.
Noah A LinhartDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.
Shivam JainDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.
Gilbert Rosario AcevedoDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.
Michael BoyceDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710.ORCID 0000-0002-2729-4876

Funding

Cell and Molecular Biology Training ProgramT32GM142605 · NIGMS · DUKE UNIVERSITY · PI MICHAEL S BOYCE, Stefano Di Talia · 2021 to 2026
$3.7M
Duke PRIME Cancer Research ProgramR25CA275731 · NCI · DUKE UNIVERSITY · PI GERARD C BLOBE, Jason Andrew Somarelli · 2023 to 2026
$850k
Cell signaling through O-linked glycosylationR35GM161290 · NIGMS · DUKE UNIVERSITY · PI MICHAEL S BOYCE · 2026 to 2026
$475k
NCI NIH HHS R25 CA275731NIGMS NIH HHS R35 GM161290NIGMS NIH HHS T32 GM142605
6 · The paper itself

Abstract

Glycosylation depends on tightly regulated pools of nucleotide-sugars (NS), yet the mechanisms controlling mammalian NS homeostasis and their downstream effects on glycoprotein biosynthesis remain poorly understood. UDP-galactose 4'-epimerase (GALE) catalyzes the reversible interconversion of UDP-galactose/UDP-glucose and UDP-

Identifiers

PMID42367921
PMCPMC13308026

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.