ArticlebioRxiv : the preprint server for biology2026
Cross-trait clustering of sub-threshold sleep genetic signals identifies EGR2 as a conserved regulator of sleep.
Kyla Mace, Khanh B Trang, Amber J Zimmerman, Erika Almeraya Del Valle, Erin N Lottes, Rebecca E Parker, Jakiah Choudhury, Alessandra Chesi, Struan F A Grant, Matthew S Kayser
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Kyla MaceDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-4548-8746 Khanh B TrangCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-9434-508X Amber J ZimmermanChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0001-8212-9059 Erika Almeraya Del ValleChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Erin N LottesDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Rebecca E ParkerCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA.
Jakiah ChoudhuryDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Alessandra ChesiCenter for Spatial and Functional Genomics, Children's Hospital of Philadelphia, Philadelphia, PA.
Struan F A GrantChronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0003-2025-5302 Matthew S KayserDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Funding
University of Pennsylvania Postdoctoral Opportunities in Research and TeachingK12GM081259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Janis K. Burkhardt · 2007 to 2026
$20.1MPREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8MTraining in Sleep & Sleep DisordersT32HL007953 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI David Menassah Raizen, AMY M SAWYER · 2000 to 2026
$10.6MElucidation of Genetic Effects on Sleep and Circadian TraitsR01HL143790 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GEHRMAN, PHILIP RICHARD, GRANT, STRUAN F A · 2018 to 2021
$3.6MInvestigating sleep regulation and function during early developmentR35NS137329 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MATTHEW S KAYSER · 2024 to 2026
$2.6MTraining Program in Chronobiology, Sleep and Sleep DisordersT32HL170968 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Philip Richard Gehrman, David Menassah Raizen · 2024 to 2026
$2.4MVariant-to-gene mapping for brain related traits and disordersR35HG011959 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI CHESI, ALESSANDRA · 2021 to 2025
$2.4MThe role of GPI-anchor biosynthesis in sleep regulationR01HL178074 · NHLBI · TEXAS A&M UNIVERSITY · PI Philip Richard Gehrman, Struan F A Grant · 2025 to 2026
$1.5MA cross-species approach to hypersomnia genetics informed by human GWASR01NS135075 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Alessandra Chesi · 2024 to 2026
$1.4MNHGRI NIH HHS R35 HG011959NHLBI NIH HHS R01 HL143790NHLBI NIH HHS R01 HL178074NHLBI NIH HHS T32 HL007953NHLBI NIH HHS T32 HL170968NIGMS NIH HHS K12 GM081259NIGMS NIH HHS T32 GM008076NINDS NIH HHS R01 NS135075NINDS NIH HHS R35 NS137329
6 · The paper itselfAbstract
Idiopathic hypersomnia (IH) is a highly heritable sleep disorder characterized by excessive daytime sleepiness, yet few genetic pathways contributing to hypersomnolence have been identified. To expand genetic discovery beyond the limited number of genome-wide significant loci associated with sleepiness-related traits, we applied multi-trait clustering to sleep-associated genetic variation that did not reach conventional significance thresholds. Integration with our cell-type-specific variant-to-gene mapping prioritized candidate effector genes for cross-species functional screening. Among the strongest candidates was
Identifiers
PMID42367892
PMCPMC13308064
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