Evidence map›Paper›PMID 42367885›Full record

ArticlebioRxiv : the preprint server for biology2026

The atypical IκB factor IκBδ enhances CD8 T cell accumulation and effector functions in solid tumors.

Barsha Dash, Xiaocui He, Arlet Lara-Custodio, Leo J Arteaga-Vazquez, Yue Zhao, Hannah Drum, Osamu Ikeda, Eric Johnson, Yuntian Zhu, Chen Zhang and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Barsha DashDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Xiaocui HeDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Arlet Lara-CustodioDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Leo J Arteaga-VazquezDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Yue ZhaoDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Hannah DrumDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Osamu IkedaDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Eric JohnsonDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Yuntian ZhuDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Chen ZhangDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Srikanth BattuDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Edahí González-AvalosDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Anjana RaoDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Patrick G HoganDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, 9420 Athena Circle, La Jolla, CA, 92037, USA.

Funding

SIGNAL TRANSDUCTION AND GENE INDUCTION IN T LYMPHOCYTESR01AI040127 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, RAO, ANJANA · 1996 to 2025
$13.3M
NFAT, bZIP proteins, and transcriptional programs in lymphocytesR01AI109842 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Patrick Hogan, Anjana Rao · 2014 to 2026
$8.6M
NovaSeq5000 High Throughput SequencerS10OD025052 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SEUMOIS, GREGORY · 2018 to 2018
$832k
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
NFAT, bZIP proteins, and transcriptional programs in lymphocytesR56AI109842 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, RAO, ANJANA · 2019 to 2019
$414k
NCRR NIH HHS S10 RR027366NIAID NIH HHS R01 AI040127NIAID NIH HHS R01 AI109842NIAID NIH HHS R56 AI109842NIH HHS S10 OD025052
6 · The paper itself

Abstract

Two prominent mechanisms by which tumors fend off immune control are by constraining the ability of T cells and CAR T cells to survive and expand in the tumor, and by restraining their ability to sustain full cytotoxic capacity. We identified IκBδ, encoded by

Identifiers

PMID42367885
PMCPMC13307950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.