Evidence map›Paper›PMID 42367878›Full record

ArticlebioRxiv : the preprint server for biology2026

Chromatin Assembly Factor 1 is required for normal structure and function of facultative heterochromatin in

Eduardo V Torres, Rochelle E Yap, Aileen R Ferraro, Collin D Link, Jacqueline F Pelham, Zachary A Lewis

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eduardo V TorresDepartment of Genetics, The University of Georgia, Athens, GA 30602.ORCID 0000-0002-1951-7320
Rochelle E YapDepartment of Microbiology, The University of Georgia, Athens, GA 30602.ORCID 0000-0002-9181-280X
Aileen R FerraroDepartment of Microbiology, The University of Georgia, Athens, GA 30602.
Collin D LinkDepartment of Microbiology, The University of Georgia, Athens, GA 30602.
Jacqueline F PelhamDepartment of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, 63110.
Zachary A LewisDepartment of Microbiology, The University of Georgia, Athens, GA 30602.ORCID 0000-0002-1735-8266

Funding

Control and function of repressive chromatin domainsR35GM152134 · NIGMS · UNIVERSITY OF GEORGIA · PI Zachary Lewis · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM152134
6 · The paper itself

Abstract

Polycomb Repressive Complex 2 (PRC2) is a conserved epigenetic regulator that represses gene expression through methylation of histone H3 lysine 27 (H3K27me3). In animals, plants, and some fungi, PRC2-directed facultative heterochromatin plays essential roles in development and cellular differentiation. Here, we show that the replication-dependent histone chaperone Chromatin Assembly Factor 1 (CAF-1) is required for proper structure and function of facultative heterochromatin in the model fungus

Indexed as

ASH1CAF-1facultative heterochromatinH3K27me3histone chaperonePolycomb repressionPRC2

Identifiers

PMID42367878
PMCPMC13307951

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.