ArticleFrontiers in immunology2026
Immunological profiling of rheumatoid factor-positive primary Sjögren's syndrome by single-cell RNA sequencing.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Research on adaptive collaborative dispatch optimization algorithms for drones in distribution networks.Scientific reports · 2026Article
- Characterization of Peripheral Blood Immune Cell Features in SSA/SSB Double‑Positive Primary Sjögren's Disease Based on Single‑Cell RNA Sequencing.Journal of inflammation research · 2026Article
- Identification and Experimental Validation of Key Biomarkers for Rheumatoid Arthritis Based on Bioinformatics Analysis and Machine Learning.Journal of inflammation research · 2026Article
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Authors and funding
8 authors.
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Abstract
Objective: Primary Sjögren's syndrome (pSS) is a highly heterogeneous autoimmune disease. Previous studies have suggested that rheumatoid factor (RF)-positive patients appear to have a higher incidence of systemic involvement. However, the underlying mechanisms remain unclear. This study aims to elucidate the potential biological mechanisms through single-cell RNA sequencing (scRNA-seq). Methods: Peripheral blood mononuclear cells from 3 healthy controls, 6 RF-negative (RF Results: Analysis of B cell subsets revealed a significantly increased proportion of plasma cells in RF Conclusion: The RF status in pSS patients is closely associated with specific immune cell profiles. RF
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