Evidence map›Paper›PMID 42367797›Full record

ReviewFrontiers in immunology2026

Innate immune recognition and immunomodulatory effects of bacteriophages: implications for phage therapy.

Tomoko Hanawa, Mayuko Tanaka, Debora Satie Nagano, Ken Shirato, Sanae Hasegawa-Ishii, Takeaki Matsuda

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tomoko Hanawa *Department of General Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Mayuko TanakaDepartment of General Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Debora Satie NaganoDepartment of General Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Ken ShiratoDepartment of Hygiene and Public Health, Kyorin University School of Medicine, Tokyo, Japan.
Sanae Hasegawa-IshiiFaculty of Health Sciences, Kyorin University, Tokyo, Japan.
Takeaki Matsuda *Department of General Medicine, Kyorin University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteriophages (phages) have been explored as a potential treatment for infectious diseases owing to their bacteriolytic ability. However, accumulating evidence indicates that phages interact with the host immune system and modulate innate immune responses. Phage particles, genomes, and phage-derived components are sensed by pattern recognition receptors, including Toll-like receptors and cytosolic nucleic acid sensors, leading to context-dependent activation or suppression of inflammatory signaling pathways, such as nuclear factor κ-light-chain-enhancer of activated B cells and type I interferon responses. In clinical settings and

Indexed as

BacteriophagesImmunity, InnateImmunomodulationPhage TherapyAnimalsHost-Pathogen InteractionsHumansInnate Immunity Recognitionbacteriophageimmunomodulatoryinnate immunityphage therapyStaphylococcus aureus

Identifiers

PMID42367797
PMCPMC13293815

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.