Evidence map›Paper›PMID 42367761›Full record

ArticleFrontiers in immunology2026

CXCR3 ameliorates neutrophil-dependent disease severity in SARS-CoV-2 infection by regulating CD4

Md Jashim Uddin, Claire Fleming, Nick R Natale, Duncan Hart, Brett Moreau, Anthony Day, Judith Allen, William A Petri

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Animals : an open access journal from MDPI · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Md Jashim UddinDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, United States.
Claire FlemingDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, United States.
Nick R NataleDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, United States.
Duncan HartDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, United States.
Brett MoreauDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, United States.
Anthony DayLydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom.
Judith AllenLydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom.
William A PetriDivision of Infectious Diseases and International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the host immune response to SARS-CoV-2 infection is critical for developing effective immunotherapeutic interventions. Using bulk RNA sequencing of lung tissue from mock-infected and mouse-adapted SARS-CoV-2 strain MA-10-infected mice, we identified CXCL9, CXCL10, and CXCL11 as among the most upregulated transcripts. Notably, their shared receptor, CXCR3, was also upregulated, suggesting activation of the CXCL9/10/11-CXCR3 axis in the lungs. Using spectral flow cytometry, we observed that the increased recruitment of CXCR3

Indexed as

CD4-Positive T-LymphocytesCOVID-19NeutrophilsReceptors, CXCR3SARS-CoV-2AnimalsChemokine CXCL10Chemokine CXCL11Chemokine CXCL9Disease Models, AnimalFemaleHumansLungMiceMice, Inbred C57BLMice, KnockoutChemokine CXCL10Chemokine CXCL11Chemokine CXCL9Cxcl11 protein, mouseCxcr3 protein, mouseReceptors, CXCR3CD4+T cellsCOVID-19CXCR3neutrophilsSARS-CoV-2

Identifiers

PMID42367761
PMCPMC13294051

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.