Case report: When Behçet's disease meets multizonal outer retinopathy and retinal pigment epitheliopathy: longitudinal multimodal imaging of an overlap phenotype.

Jiang Jikuan, Cheng Yizhe, Chen Chunli

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Jiang JikuanBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.

Cheng YizheState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

Chen ChunliBeijing Tongren Hospital, Capital Medical University, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To report a rare case of overlapping features of Behçet's uveitis and multizonal outer retinopathy and retinal pigment epitheliopathy (MORR), documented by longitudinal multimodal imaging. Methods: A single case report. Results: A 37-year-old male presented with unilateral, painless, progressive vision loss and a history of recurrent oral ulcers. Multimodal imaging with longitudinal follow-up documented bilateral, progressive outer retinopathy concurrent with retinal vasculitis. These features characterize an acute progressive episode not previously described. Conclusion: This case highlights the importance of multimodal imaging and reminds clinicians to remain vigilant to possible concurrent outer retinopathy in Behçet's uveitis. Furthermore, given the favorable treatment response observed here, this case also offers a reference for the therapeutic strategy of MORR.

Indexed as

Behcet SyndromeMultimodal ImagingRetinal DiseasesRetinal Pigment EpitheliumAdultFluorescein AngiographyHumansMalePhenotypeRetinal VasculitisTomography, Optical CoherenceBehçet’s diseasecase reportmultimodal imagingmultizonal outer retinopathy and retinal pigment epitheliopathyretinal vasculitis

Identifiers

PMID42367760

DOI10.3389/fimmu.2026.1867734

PMCPMC13303698

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