Evidence map›Paper›PMID 42367754›Full record

ReviewFrontiers in immunology2026

Spatial immune archetypes in gastric and colorectal cancer: a proposed conceptual framework for immunotherapy resistance and therapeutic remodeling.

Songlin Sun, Yicong Zeng, Jiahan Chen, Yang Zhong, Tong Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Songlin SunSecond Department of Gastrointestinal Surgery, Hepatobiliary, Pancreatic and Intestinal Diseases Research Institute, The Affiliated Hospital of North Sichuan Medical College, National Clinical Key Specialty (General Surgery), Sub-center of National Clinical Research Center for Digestive Diseases, Sichuan Clinical Research Center for Digestive Diseases, Nanchong, Sichuan, China.
Yicong ZengSecond Department of Gastrointestinal Surgery, Hepatobiliary, Pancreatic and Intestinal Diseases Research Institute, The Affiliated Hospital of North Sichuan Medical College, National Clinical Key Specialty (General Surgery), Sub-center of National Clinical Research Center for Digestive Diseases, Sichuan Clinical Research Center for Digestive Diseases, Nanchong, Sichuan, China.
Jiahan ChenSecond Department of Gastrointestinal Surgery, Hepatobiliary, Pancreatic and Intestinal Diseases Research Institute, The Affiliated Hospital of North Sichuan Medical College, National Clinical Key Specialty (General Surgery), Sub-center of National Clinical Research Center for Digestive Diseases, Sichuan Clinical Research Center for Digestive Diseases, Nanchong, Sichuan, China.
Yang ZhongSecond Department of Gastrointestinal Surgery, Hepatobiliary, Pancreatic and Intestinal Diseases Research Institute, The Affiliated Hospital of North Sichuan Medical College, National Clinical Key Specialty (General Surgery), Sub-center of National Clinical Research Center for Digestive Diseases, Sichuan Clinical Research Center for Digestive Diseases, Nanchong, Sichuan, China.
Tong ZhouSecond Department of Gastrointestinal Surgery, Hepatobiliary, Pancreatic and Intestinal Diseases Research Institute, The Affiliated Hospital of North Sichuan Medical College, National Clinical Key Specialty (General Surgery), Sub-center of National Clinical Research Center for Digestive Diseases, Sichuan Clinical Research Center for Digestive Diseases, Nanchong, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric and colorectal cancers are leading causes of global cancer mortality, yet the transformative benefits of immune checkpoint blockade remain largely confined to the small fraction of patients with MSI-H/dMMR tumors. The vast majority-those with MSS/pMMR disease-exhibit primary resistance, underscoring an urgent need to look beyond bulk immune infiltration and dissect the

Indexed as

Colorectal NeoplasmsDrug Resistance, NeoplasmImmunotherapyStomach NeoplasmsAnimalsHumansSpatial TranscriptomicsTumor Microenvironmentcolorectal cancergastric cancerimmunotherapy resistanceMSS/pMMRspatial immune archetypesspatial transcriptomicstranslational medicinetumor microenvironment

Identifiers

PMID42367754
PMCPMC13294141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.