Evidence map›Paper›PMID 42367742›Full record

ArticleBiophysics reports2026

Tracheal nebulization of AAV-CRE for lung conditional knockout model construction and whole lung clearing.

Lihong Ye, Xiyue Yan, Dacheng Yang, Shuang Wu, Wandong Chen, Wei Kevin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysics reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lihong YeGraduate School of Guangzhou Medical University, Guangzhou 511436, China.
Xiyue YanGuangzhou National Laboratory, Guangzhou 510005, China.
Dacheng YangGraduate School of Guangzhou Medical University, Guangzhou 511436, China.
Shuang WuGraduate School of Guangzhou Medical University, Guangzhou 511436, China.
Wandong ChenGuangzhou National Laboratory, Guangzhou 510005, China.
Wei Kevin ZhangGraduate School of Guangzhou Medical University, Guangzhou 511436, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of lung-specific conditional knockout animal models is pivotal in advancing lung disease research. This protocol describes the experimental procedures in detail, including the construction of loxP mice, endotracheal tube nebulization of adeno-associated virus (AAV) and whole lung clearing. Mouse lung conditional knockouts were successfully constructed. This meticulous approach allows for accurate control over the timing and location of the knockout, facilitating an in-depth investigation into the pathogenesis of lung diseases and the development of therapeutic strategies. These lung-specific conditional knockout models represent a powerful tool for the study of lung diseases, offering valuable insights and guidance for the advancement of treatment approaches and drug discovery in the future.

Indexed as

AAVCre-loxP mouse modelLung condition knockoutTracheal nebulizationWhole lung clearing

Identifiers

PMID42367742
PMCPMC13294202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.