Two-step Xenogeneic Dermal Matrix-assisted Autologous Skin Grafting for Large Scalp Cutaneous Squamous Cell Carcinoma Ulcer.

Yuhuan Peng, Nian Chen, Xiaoliu Wang, Zhengyang Li, Hui Wang, Ruiling Wen, Xiangping Xu, Yiping Wang, Chiyu Jia

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In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Yuhuan PengFrom the Center of Burn and Plastic and Wound Healing Surgery, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Nian ChenFrom the Center of Burn and Plastic and Wound Healing Surgery, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Xiaoliu WangDepartment of Dermatology, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Zhengyang LiFrom the Center of Burn and Plastic and Wound Healing Surgery, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Hui WangFrom the Center of Burn and Plastic and Wound Healing Surgery, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Ruiling WenFrom the Center of Burn and Plastic and Wound Healing Surgery, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Xiangping XuFrom the Center of Burn and Plastic and Wound Healing Surgery, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Yiping WangFrom the Center of Burn and Plastic and Wound Healing Surgery, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Chiyu JiaFrom the Center of Burn and Plastic and Wound Healing Surgery, Hengyang Medical School, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (CSCC) of the scalp poses major reconstructive challenges, especially in older patients with poor surgical tolerance. Large postexcisional defects often require complex reconstruction, whereas free flaps and tissue expansion may be unsafe in high-risk individuals. We present a cost-effective, 2-stage approach using xenogeneic acellular dermal matrix (XADM) followed by autologous split-thickness skin grafting. The graft survived completely. Both scalp and donor site healed without infection or wound complications. Frozen sections confirmed negative margins, and final histopathology showed moderately differentiated CSCC without bone invasion. Telephone follow-up indicated durable wound healing without local breakdown until death. The patient died 13 months postoperatively from systemic progression of advanced CSCC rather than surgical complications; formal oncologic surveillance was not performed because of financial constraints. Two-stage XADM-assisted autologous skin grafting is a technically accessible, economical option for large scalp CSCC defects in older, high-risk patients, avoiding free flap morbidity while achieving satisfactory healing and oncologic safety. Prospective studies are warranted. An 82-year-old woman with severe malnutrition (41 kg, 155 cm, body mass index 17.07 kg/m

Identifiers

PMID42367710

DOI10.1097/GOX.0000000000007855

PMCPMC13300597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.