Evidence map›Paper›PMID 42367668›Full record

ArticleEULAR rheumatology open2025

Interdisciplinary Clinical Practice Guidelines for patient-centred management of juvenile-onset systemic lupus erythematosus.

Kirsten Mönkemöller, Lutz T Weber, Martin Häusler, Tilmann Kallinich, Susanne Benseler, Hermine I Brunner, Caroline Bieber, Jürgen Brunner, Christoph Deuter, Gabriele Hahn and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EULAR rheumatology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Kirsten MönkemöllerDepartment of Pediatrics, Pediatric Rheumatology, Kinderkrankenhaus Amsterdamer Strasse, Cologne, Germany.
Lutz T WeberPediatric Nephrology, Children's and Adolescents' Hospital, University Hospital of Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany.
Martin HäuslerDepartment of Pediatrics, Division of Pediatric Neurology, RWTH Aachen University, Aachen, Germany.
Tilmann KallinichDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Susanne BenselerRheumatology, Childrens Health Ireland, and University College Dublin, Ireland, Dublin, Ireland.
Hermine I BrunnerUC Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Caroline BieberDepartment of Child and Adolescent Psychiatry, University Hospital and Medical Faculty Carl Gustav Carus,Technische Universität Dresden, Dresden, Germany.
Jürgen BrunnerDepartment of Pediatrics, Medical University Innsbruck, Innsbruck and Department of Medicine,Faculty of Medicine and Dentistry, Danube Private University, Krems, Austria.
Christoph DeuterCentre for Ophthalmology, University Hospital Tuebingen, Tuebingen, Germany.
Gabriele HahnDepartment of Radiology, Faculty of Medicine Carl Gustav Carus, TU, Dresden, Germany.
Christian HedrichDepartment of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Claas HinzeDepartment of Pediatric Rheumatology and Immunology, Münster University Hospital, Münster, Germany.
Anton HospachCenter for Pediatric Rheumatology, Klinikum Stuttgart, Stuttgart, Germany.
Heike-Katharina Hoyer-KuhnDepartment of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Ales JandaDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Dirk KamitzPraxis Kamitz, Kinder- und Jugendmedizin und Kinderrheumatologie, Aachen, Germany.
Min Ae Lee-KirschDepartment of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Ulrich NeudorfDivision of Pediatric Cardiology and Rheumatology, University Hospital Essen, Essen, Germany.
Jörg ReichertDepartment of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Martin AringerDivision of Rheumatology, Department of Medicine III, and University Centre for Autoimmune and Rheumatic Entities (UCARE), University Medical Centre and Faculty of Medicine, TU Dresden, Dresden, Germany.
Sabine SchanzeLupus Erythematodes Selbsthilfegemeinschaft e.V. (lupus patient organisation), Wuppertal, Germany.
Nicolaus SchwerkClinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; German Center for Lung Research (DZL/BREATH), Hannover, Germany.
Merle SeumeGerman Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Dresden, Germany.
Fabian SpethDepartment of Paediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Norbert WagnerDepartment of Pediatrics, Pediatric Rheumatology, RWTH Aachen University, Aachen, Germany.
Matthias SchneiderDepartment of Rheumatology & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany.
Burkhard TönshoffDepartment of Pediatrics I, University Children's Hospital, Heidelberg, Germany.
Klaus TenbrockDepartment of Pediatrics, Pediatric Rheumatology, RWTH Aachen University, Aachen, Germany.
Dieter HaffnerDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany.
Catharina SchuetzDepartment of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To develop updated interdisciplinary clinical practice guidelines for the management of juvenile-onset systemic lupus erythematosus (jSLE) in a patient-centred, treat-to-target (T2T) approach. Methods: Recommendations were developed based on T2T principles around shared decision-making by a multidisciplinary team of experts including paediatric and adult rheumatologists, paediatric nephrologists, neurologists, cardiologists, pneumologists, radiologists, immunologists, and infectious disease specialists, geneticists, and ophthalmologists from Germany, Switzerland, Austria, the United Kingdom and Ireland, a psychologist, and a patient representative. The process followed the standard operating procedures of the German AWMF (Association of the Scientific Medical Societies in Germany). The team conducted an extensive literature review (2012-2024) of 40 clinically selected Population/Intervention/Comparison/Outcome questions. Overarching principles (OAP), overarching treatment strategies (OATS), and recommendations were formulated and explored in 2 online preconsensus meeting Delphi surveys with the experts. The results were discussed in 3 virtual consensus meetings using a modified nominal group technique to discuss, modify and vote on the OAP, OATS, and recommendations. All final document was approved by 2 external reviewers and the AWMF. Results: We reached consensus on 45 recommendations on the general assessment, diagnosis, monitoring, nonpharmacologic, and pharmacologic management of jSLE. We highlight organ-specific manifestations, such as central nervous system disease, jSLE-related antiphospholipid antibody syndrome, and juvenile lupus nephritis, and consider disease severity for treatment recommendations. Conclusions: We have developed updated interdisciplinary clinical practice guidelines to facilitate a patient-centred T2T approach to the management of patients with jSLE.

Identifiers

PMID42367668
PMCPMC13292277

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.