ReviewEULAR rheumatology open2025
Support needs and non-pharmacological interventions for adults with mixed connective tissue disease: a systematic literature review.
Review in EULAR rheumatology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The objective of this study was to systematically review and assess the quality of the evidence regarding (1) the need for non-pharmacological support of adult patients with mixed connective tissue disease (MCTD) and (2) the elements of non-pharmacological interventions delivered to patients with MCTD. Methods: A systematic literature search was conducted in August 2024 across 4 databases: Embase, CINAHL, CENTRAL, and Medline, using diverse terminologies for MCTD. The quality of the selected studies was assessed with the Critical Appraisal Skills Programme tools for qualitative and case-control studies, and results were summarised narratively. The study protocol was preregistered with PROSPERO (ID: CRD42024591268). Results: The search yielded 7091 unique records, with 4 articles meeting the inclusion criteria after screening. Three studies with varying quality assessments (1 low and 2 high) identified patient support needs across 3 domains: educational, mental health, and pregnancy-related needs. A fourth study, found to be of low quality, assessed a non-pharmacological intervention, specifically a tandem-psychotherapy approach. Conclusions: This review with a narrative synthesis highlights a significant gap in high-quality evidence regarding non-pharmacological support for patients with MCTD. It underscores the urgent need for further research to better understand and address the non-pharmacological needs of this population, facilitating the development of effective interventions for managing the complexity of MCTD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.