Evidence map›Paper›PMID 42367575›Full record

ReviewMedical cannabis and cannabinoids

Pharmacokinetics of Cannabinoids Delivered by Diverse Routes in Rodents.

Shivani S Godbole, Wesley M Raup-Konsavage, Kent E Vrana

Abstract readReview
In one paragraph

Review in Medical cannabis and cannabinoids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shivani S GodboleDepartment of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA, USA.
Wesley M Raup-KonsavageDepartment of Neuroscience and Experimental Therapeutics, Penn State College of Medicine, Hershey, PA, USA.
Kent E VranaCenter for Cannabis and Natural Product Pharmaceutics, Penn State College of Medicine, Hershey, PA, USA.

Funding

AI-based Mapping of Complex Cannabis Extracts in Pain PathwaysR01AT012053 · NCCIH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Nikolay Dokholyan, KENT E VRANA · 2023 to 2026
$2.4M
NCCIH NIH HHS R01 AT012053
6 · The paper itself

Abstract

Background: The rising popularity of medicinal and recreational use of Summary: While inhalation and ingestion are the most common routes of cannabinoid delivery in humans, injections (intraperitoneal or subcutaneous) are most common in animal models due to the inherent ease of dosing. Human pharmacokinetic studies utilizing the intravenous parenteral route of administration of cannabinoids (specifically Δ Key Messages: To assess the use of cannabinoids as an alternative therapeutic option, it is important to test patient-compliant formulations and routes of administration. Further, since bioavailability of cannabinoids varies greatly with the route of administration, mimicking human cannabinoid drug delivery in animal models becomes crucial. This review provides insights into cannabinoid pharmacokinetics across different delivery routes in rodent models and the translatability to humans.

Indexed as

CannabinoidsDelivery systemsPharmacokineticsRodents

Identifiers

PMID42367575
PMCPMC13299164

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.