Computed Tomography-Guided and Magnetic Resonance-Guided Adaptive Radiotherapy for Gynecological Stereotactic Body Radiotherapy Treatments: A Dosimetry and Workflow Analysis.

Dishane C Luximon, Rojine T Ariani, John Charters, Dylan O'Connell, Puja Venkat

Abstract read

In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Dishane C LuximonDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, USA.

Rojine T ArianiDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, USA.

John ChartersDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, USA.

Dylan O'ConnellDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, USA.

Puja VenkatDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the dosimetric benefit of online adaptive radiotherapy (oART) for adjuvant gynecological stereotactic body radiotherapy (SBRT) and to compare plan quality and workflow efficiency between computed tomography-guided adaptive radiotherapy (CTgART) and magnetic resonance-guided adaptive radiotherapy (MRgART) platforms. MATERIALS AND

methodsTen patients (50 fractions) treated between September 2024 and October 2025 were analyzed (CTgART: 35 fractions; MRgART: 15 fractions). Each adapted plan was compared with its corresponding non-adapted plan recalculated on the anatomy of the day. Wilcoxon signed-rank tests (W) were used to determine statistical significance (p < 0.05). Adapted plans between CTgART and MRgART were compared dosimetrically using Mann-Whitney U tests (U) for statistical significance (p < 0.05). For each comparison, the dose constraints defined by the trial protocol were used as a baseline. Timestamps from each adaptive system were extracted from the system logs and compared for each fraction.

resultsDaily adaptation substantially improved paravaginal planning target volume (PTV) coverage (V28.5Gy

conclusionsOnline adaptation is essential to consistently meet protocol targets in gynecological SBRT, enhancing both target coverage and organs at risk sparing. While CTgART and MRgART can both achieve clinically acceptable plans, the CTgART workflow currently demonstrates superior workflow efficiency.

Indexed as

endometrial cancerendometrial cancer (ec)online adaptive radiotherapy (online-art)radiotherapy workflowstereotactic body radiotherapy (sbrt)uterine cervical cancer

Identifiers

PMID42367530

DOI10.7759/cureus.109751

PMCPMC13308741

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