Evidence map›Paper›PMID 42367433›Full record

ArticleCureus2026

Prolonged Neurological Depression, Bradycardia, and Gastroparesis Following Acute Oral Cannabinoid Ingestion: A Case Report.

Nikos Adamidis, Sofia Adamidi, Vasiliki E Georgakopoulou, Athanasios Desalermos, Argyroula Karampela, Sofia Miliou, Eleni Valavani, Sotirios Adamidis

Abstract readCase Reports
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nikos AdamidisFirst Department of Internal Medicine, Sismanogleio General Hospital, Athens, GRC.
Sofia AdamidiDepartment of Internal Medicine, Charlton Memorial Hospital, Fall River, USA.
Vasiliki E GeorgakopoulouDepartment of Pathophysiology, Laiko General Hospital, Athens, GRC.
Athanasios DesalermosMedical School, Harvard University, Cambridge, USA.
Argyroula KarampelaFirst Department of Internal Medicine, Athens Medical Center, Athens, GRC.
Sofia MiliouFirst Department of Internal Medicine, Athens Medical Center, Athens, GRC.
Eleni ValavaniDepartment of Primary Education, National and Kapodistrian University of Athens, Athens, GRC.
Sotirios AdamidisFirst Department of Internal Medicine, Athens Medical Center, Athens, GRC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabis-containing edibles may be associated with clinically relevant intoxication, particularly when symptom onset is delayed and the clinical presentation is nonspecific. A 54-year-old man with treated dyslipidemia presented with worsening vertigo, dizziness, headache, slurred speech, psychomotor slowing, and generalized weakness after ingesting a cannabis-containing cookie. Symptoms began approximately three hours after ingestion and progressed to slurred speech and bradypsychia by 12 hours. On admission, he was awake but markedly bradykinetic and bradypsychic, with diffuse weakness and epigastric distension. Stroke workup, including brain CT, computed tomography angiography, and brain MRI, excluded intracranial hemorrhage, acute ischemia, and large-vessel occlusion. Chest CT was unremarkable, while abdominal CT showed marked gastric distension with retained gastric contents, compatible with acute gastric dysmotility/suspected gastroparesis, requiring Levin tube decompression. Cerebrospinal fluid studies and infectious testing were negative. Cardiac evaluation showed sinus bradycardia, with Holter monitoring revealing a mean heart rate of 48 beats/min and a nadir of 35 beats/min, without significant pauses or conduction abnormalities. Electroencephalography showed generalized slowing without epileptiform activity. Following consultation with the Poison Control Center, cannabinoid intoxication was considered the most likely diagnosis. The patient received supportive care with monitoring, intravenous fluids, and gastric decompression. His clinical condition improved from day three, and he was discharged fully recovered on day six. Cannabis-containing edible ingestion should be considered in the differential diagnosis of acute or subacute neurological symptoms when compatible exposure is reported. In this case, the presentation included bradypsychia, bradykinesia, slurred speech, bradycardia, and acute gastric dysmotility/suspected gastroparesis, initially raising concern for stroke or central nervous system infection. Careful diagnostic evaluation remains necessary to exclude serious alternative causes, but recognition of this possibility may help guide appropriate supportive management.

Indexed as

cannabinoid intoxicationcannabis ediblegastroparesissinus bradycardiastroke mimic

Identifiers

PMID42367433
PMCPMC13294481

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.