ArticleCureus2026
Silent Synergy: Is the Presence of Concurrent β-Lactamase Mechanisms Undermining Antimicrobial Effectiveness?
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background The worldwide escalation of antimicrobial resistance poses a substantial challenge to the effective management of both community-acquired and hospital-associated infections. Among Gram-negative bacteria, resistance to β-lactam antibiotics is predominantly mediated by enzymes such as extended-spectrum β-lactamases, AmpC β-lactamases, and metallo-β-lactamases. Aim This study aimed to identify the concurrent production of these β-lactamase mechanisms in Gram-negative clinical isolates. Materials and methods A cross-sectional laboratory-based study was performed on 185 non-duplicate Enterobacteriaceae isolates obtained from clinical specimens. All the isolates underwent phenotypic screening for extended spectrum of β-lactamases (ESBL), AmpC, and metallo-β-lactamases (MBL) production using standard disk diffusion-based methods. The study adhered to ethical guidelines with institutional approval. Data were analyzed statistically using the Chi-square test, with significance set at p < 0.05. Results Out of 185 Enterobacteriaceae isolates,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.