Evidence map›Paper›PMID 42367322›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2026

Phenotypic profiling of Pathogen Box compounds MMV667494 and MMV028694 in bloodstream-form

Pearl Ihuoma Akazue, Neils Ben Quashie, Sue Vaughan, Harry P de Koning, Theresa Manful Gwira

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Article in Experimental biology and medicine (Maywood, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pearl Ihuoma AkazueWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.
Neils Ben QuashieWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.
Sue VaughanDepartment of Biological and Medical Sciences, Oxford Brookes University, Oxford, United Kingdom.
Harry P de KoningSchool of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom.
Theresa Manful GwiraWest African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Open-access drug discovery platforms have accelerated hit identification and lead prioritization across multiple diseases and enable systematic repurposing of bioactive compounds beyond their original indications. However, there remains a need for new chemotypes for African trypanosomiasis with improved efficacy and resilience to emerging drug resistance. In this study, we evaluated the antitrypanosomal potential and cellular effects of two Pathogen Box compounds, MMV667494 and MMV028694. The compounds were selected through a resazurin-based

Indexed as

Trypanocidal AgentsTrypanosoma brucei bruceiAnimalsFlow CytometryMembrane Potential, MitochondrialPhenotypeReactive Oxygen SpeciesTrypanosomiasis, AfricanReactive Oxygen SpeciesTrypanocidal AgentsAfrican trypanosomiasisantitrypanosomal activitymitochondrial reactive oxygen speciesmitochondrial stressPathogen Box

Identifiers

PMID42367322
PMCPMC13303395

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.