Evidence map›Paper›PMID 42367295›Full record

ArticleFrontiers in pharmacology2026

Tripterygium wilfordii Hook F accelerates CD4

Liyuan Zheng, Fada Wang, Xiaojing Song, Leidan Zhang, Yanling Li, Wei Lv, Yang Han, Wei Cao, Taisheng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liyuan Zheng *Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Fada Wang *Department of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Xiaojing SongDepartment of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Leidan ZhangDepartment of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Yanling LiDepartment of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Wei LvDepartment of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Yang HanDepartment of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Wei CaoDepartment of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Taisheng LiDepartment of Infectious Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Incomplete immune reconstitution (INR) affects 9%-45% of ART-treated people living with HIV (PLWH) and is associated with increased morbidity and mortality. Chronic immune activation and inflammatory signaling, particularly via the IP-10/CXCL10 pathway, are central to its pathogenesis. Whether Tripterygium wilfordii Hook F (TwHF), an immunomodulatory agent with established anti-inflammatory properties, can improve CD4 Methods: We conducted a retrospective longitudinal cohort study at Peking Union Medical College Hospital. ART-treated, virologically suppressed PLWH with persistent CD4 Results: TwHF was associated with a significantly accelerated rate of CD4 Conclusion: TwHF accelerates CD4

Indexed as

antiretroviral therapyCD4 T-cell recoveryHIVimmune activationincomplete immune reconstitutioninflammatory chemokinesTripterygium wilfordii Hook F

Identifiers

PMID42367295
PMCPMC13299095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.