Evidence map›Paper›PMID 42367244›Full record

ArticleMolecular therapy. Nucleic acids2026

Detection of mutant cancer-derived circRNAs in extracellular vesicles by rolling circle amplification.

Mikołaj Piotr Zaborowski, Charles Pin-Kuang Lai, Alessandro Sammarco, Bence György, Xuan Zhang, Kyungheon Lee, Young Jeong Na, Lorenzo Ceppi, Koen Breyne, Elizabeth Marie Champagne and 8 more

Abstract read
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In one paragraph

Article in Molecular therapy. Nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mikołaj Piotr ZaborowskiDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Charles Pin-Kuang LaiDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Alessandro SammarcoDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Bence GyörgyDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Xuan ZhangDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Kyungheon LeeCenter for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Young Jeong NaCancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Lorenzo CeppiCancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Koen BreyneMolecular Neurogenetics Unit, Department of Neurology, MGB Neuroscience Institute, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Elizabeth Marie ChampagneMolecular Neurogenetics Unit, Department of Neurology, MGB Neuroscience Institute, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Jack CardiniGene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA 02139, USA.
Robert Alexander WesselhoeftGene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA 02139, USA.
Marcin IwanickiDepartment of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Michael J BirrerCancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Hakho LeeCenter for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Bakhos A TannousDepartment of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Xandra O BreakefieldDepartment of Neurology and Radiology, Massachusetts General Hospital, MGB Neuroscience Institute, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNAs (circRNAs) form during splicing as a closed ring and are more resistant to degradation than linear RNAs. Cells release circRNAs within membrane-bound extracellular vesicles (EVs), which transport DNA, RNA, and proteins. Whether circRNAs in EVs can be used as biomarkers remains uncertain. We aimed to identify mutant circRNAs in EVs to develop a new biomarker approach. We demonstrated that ovarian cancer cells release and enrich circRNAs in EVs. We detected mutant circular transcripts from

Indexed as

cancer biomarkerscancer mutationscircRNAsextracellular vesiclesMT: non-coding RNAsrolling circle amplification

Identifiers

PMID42367244
PMCPMC13293672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.