ArticleMedicina oral, patologia oral y cirugia bucal2026
Aberrant expression and subcellular localization of laminin 332 in oral squamous cell carcinoma: Implications for invasive front assessment.
Article in Medicina oral, patologia oral y cirugia bucal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLaminin 332 (LM332) is a primary component of the epithelial BM. During malignant transformation, loss of continuity and cytoplasmic redistribution have been documented during tumor progression. This study aimed to evaluate LM332 expression at the basement membrane (BM) and in the cytoplasm of oral squamous cell carcinoma (OSCC) and to investigate its association with histopathological characteristics. MATERIAL AND
methodsA cross-sectional study was conducted on 130 patients utilizing immunohistochemical techniques to examine LM332 expression.
resultsIn OSCC, LM332 expression at the BM was frequently fragmented in 62% of cases and absent in 18%. Conversely, LM332 was significantly overexpressed in the cytoplasm, with 95% of cases exhibiting positive staining (≥1+ based on the semi-quantitative scoring system). A statistically significant difference was observed between LM332 expression and the histological grade of OSCC (p<0.05).
conclusionsLM332 immunohistochemical expression patterns may serve as an adjunctive marker reflecting histopathological progression in malignant oral epithelium.
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