ArticleTurk gogus kalp damar cerrahisi dergisi2026
Relationship between serum potassium concentration, NT-pro-BNP, and risk of MACE in elderly patients with chronic heart failure.
Article in Turk gogus kalp damar cerrahisi dergisi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to investigate the association between serum potassium concentration, N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) levels, and short-term major adverse cardiovascular events (MACE) in elderly patients with chronic heart failure (CHF) after percutaneous coronary intervention (PCI), and to evaluate their predictive value. Methods: General clinical characteristics, echocardiographic parameters, and laboratory indices were collected from 124 enrolled patients. All patients were followed for 3 months beginning immediately after PCI, encompassing both the in-hospital and post-discharge periods. According to the occurrence of MACE (defined as cardiovascular death, non-fatal myocardial infarction, stroke, or rehospitalization due to worsening heart failure) during follow-up, patients were categorized into a MACE group (n=44) and a non-MACE group (n=80). Multivariate logistic regression analysis was performed to identify independent factors associated with MACE. Restricted cubic spline (RCS) analysis was used to evaluate the dose-response relationships between serum potassium concentration, NT-pro-BNP levels, and MACE risk. Receiver operating characteristic (ROC) curve analysis was conducted to assess the predictive performance of each indicator individually and in combination. Results: Multivariate logistic regression analysis demonstrated that each natural log-unit increase in NT-pro-BNP (corresponding to an approximately 2.72-fold increase in NT-pro-BNP concentration) was an independent risk factor for MACE (odds ratio [OR] =1.27), whereas each 0.1 mmol/L increase in serum potassium concentration was independently associated with a lower risk of MACE (OR =0.82). RCS analysis revealed a non-linear inverse association between serum potassium concentration and MACE risk, whereas NT-pro-BNP levels showed a significant positive association with MACE risk. The area under the ROC curve for the combined assessment of serum potassium and NT-pro-BNP was 0.73, which was significantly greater than that of either biomarker alone. Conclusion: Hypokalemia and elevated NT-pro-BNP levels are closely associated with an increased short-term risk of MACE in elderly patients with CHF. The combined assessment of these two indicators may provide clinical value for the early identification of high-risk patients.
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