ArticleRapid communications in mass spectrometry : RCM2026
Effect of Humidity on Ionisation and Ion Chemistry in Active-Capillary Dielectric Barrier Discharge Ionisation.
Article in Rapid communications in mass spectrometry : RCM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
rationaleDielectric barrier discharge ionisation (DBDI) in an active-capillary configuration (including the commercial SICRIT source) is widely used as a soft, ambient-pressure ionisation method for vapours and gases, yet the role of water vapour in controlling reagent ion chemistry and analytical behaviour has not been mechanistically described. Thus, it is necessary to understand how carrier gas humidity governs reagent ion populations and product ion formation in a DBDI source.
methodsA SICRIT ion source was coupled to a triple-quadrupole mass spectrometer and operated under constant discharge conditions while switching the carrier gas between humidified and nominally dry air. Ketones and short-chain carboxylic acids were introduced at trace vapour concentrations using permeation or diffusion tubes. Reagent ion and analyte mass spectra were acquired in full-scan mode. Selected analyte ions were subjected to collision-induced dissociation (CID) to compare in-source fragments with those formed from protonated molecules.
resultsUnder humid conditions, the reagent ion population was dominated by hydrated hydronium ions. Analytes yielded mainly protonated molecules, MH
conclusionsThese results highlight humidity as a key operational active-capillary DBDI parameter; varying it enables both low-fragmentation ionisation in humid mode and more energetic fragmenting ionisation in dry mode. The humid mode facilitates reproducible quantitation, whereas the dry mode allows structural discrimination, exemplified by differentiation of hexanone isomers.
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