ArticleDiagnostic cytopathology2026
Diagnostic Value of CCL2 and CCR2 in Pleural Effusion for Distinguishing Lung Cancer Histological Subtypes: A Retrospective Study.
Article in Diagnostic cytopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The CCL2-CCR2 axis in primary lung cancer and pulmonary metastasis: from molecular mechanisms to therapeutic potentials.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study evaluated the diagnostic value of C-C motif chemokine ligand 2 (CCL2) and C-C chemokine receptor type 2 (CCR2) in pleural effusions for distinguishing histological subtypes of lung cancer (LC).
methodsA retrospective cohort study was conducted on 96 cases of squamous cell carcinoma (LUSC), 206 cases of lung adenocarcinoma (LUAD), and 53 cases of small cell LC (SCLC). A control group of 102 patients with parapneumonic effusion was selected. CCL2 and CCR2 levels in pleural effusions were measured. Pearson correlation analysis and receiver operating characteristic curve analysis were conducted.
resultsPleural effusion CCL2 and CCR2 levels were higher in advanced LC than in parapneumonic effusion, and the changes in these two levels showed a moderate positive correlation (p < 0.001). CCL2 and CCR2 levels in pleural effusions were elevated in LUAD patients compared to LUSC and SCLC patients (p < 0.01), with SCLC patients having higher levels than LUSC patients (p < 0.01). The AUC for the combined CCL2 and CCR2 panel was higher than that for CCL2, CCR2, carcinoembryonic antigen, and cytokeratin fragment antigen 21-1 tested individually (all p < 0.05).
conclusionPatients with advanced LC exhibit elevated CCL2 and CCR2 levels in pleural effusions. Combined detection of these two markers has some diagnostic value in distinguishing between LUAD and LUSC, serving as a valuable supplement to histopathological examination; however, clinical application should involve a comprehensive assessment in conjunction with other auxiliary tests. These markers have limited value in distinguishing between SCLC and NSCLC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.