Evidence map›Paper›PMID 42366564›Full record

ArticleFEBS open bio2026

Dose-dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction.

Maren Jinks, Garth L Maker, Emily C Davies, Berin A Boughton, Samantha Lodge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maren JinksCentre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Building, Murdoch University, Perth, Australia.ORCID https://orcid.org/0009-0008-7056-2101
Garth L MakerCentre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Building, Murdoch University, Perth, Australia.
Emily C DaviesCentre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Building, Murdoch University, Perth, Australia.
Berin A BoughtonLa Trobe Institute for Sustainable Agriculture and Food, AgriBio, La Trobe University, Bundoora, Australia.
Samantha LodgeCentre for Computational and Systems Medicine, Health Futures Institute, Harry Perkins Building, Murdoch University, Perth, Australia.ORCID https://orcid.org/0000-0001-9193-0462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vitro liver models combined with metabolomics approaches offer promising alternatives to animal testing in toxicology. In this study, we investigated concentration-dependent effects of hydrogen peroxide (H

Indexed as

cytochrome P450HepG2hydrogen peroxidein vitro toxicologymetabolomicsmodel systems

Identifiers

PMID42366564
PMCPMC13398862

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.