ArticleChemical research in toxicology2026
DNA Structure-Dependent Enrichment of Oxidative Lesions.
Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oxidative DNA lesions such as 8-oxo-7,8-dihydroguanine (8-oxoG) and abasic (AP) sites contribute to mutagenesis and genetic instability. H-DNA, a naturally occurring intramolecular triplex structure, promotes genetic instability and is susceptible to oxidative damage. Here, we examined how oxidative lesions distribute within an H-DNA-forming sequence. Although oxidative stress increased oxidized purines overall, no template-dependent differences were detected at a distal B-DNA locus. In contrast, AP sites and FPG-sensitive lesions were enriched within the H-DNA region relative to the B-DNA control, even under basal conditions. These findings indicate that H-DNA topology enhances local susceptibility to oxidative damage and shapes the spatial distribution of oxidative DNA lesions that can contribute to mutagenesis.
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