Evidence map›Paper›PMID 42366513›Full record

ArticleNMR in biomedicine2026

Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.

Filip Szczepankiewicz, Malwina Molendowska, Samo Lasič, Marcella E Safi, Michael Gottschalk, Evangelia Sereti, Anders Bjartell, Linda Knutsson, Oskar Vilhelmsson Timmermand, Crister Ceberg and 1 more

Abstract read
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Human In Vivo Validation of Frequency-Dependent QTI.Magnetic resonance in medicine · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Filip SzczepankiewiczDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-5251-587X
Malwina MolendowskaDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0001-8540-8424
Samo LasičDepartment of Diagnostic Radiology, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-9284-7182
Marcella E SafiDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.
Michael GottschalkLund University Bioimaging Centre, Lund University, Lund, Sweden.
Evangelia SeretiDepartment of Translational Medicine, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-5947-9971
Anders BjartellDepartment of Translational Medicine, Lund University, Malmö, Sweden.
Linda KnutssonDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID https://orcid.org/0000-0002-4263-113X
Oskar Vilhelmsson TimmermandDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.
Crister CebergDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.
Joanna StrandDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.

Funding

ALF Foundation of the Medical Faculty of Lund University ALF-YF 40631Mrs. Berta Kamprad Foundation FBKS-2021-24-(344)Mrs. Berta Kamprad Foundation FBKS-2022-41-(425)Mrs. Berta Kamprad Foundation FBKS-2024-23-(608)Swedish Cancer Society 22 0533 FESwedish Cancer Society 22 0592 JIASwedish Cancer Society 22 2011 PjSwedish Prostate Cancer FederationSwedish Research Council 2021-04844The Crafoord Foundation 20240791The Thelma Zoéga Foundation for Medical Research
6 · The paper itself

Abstract

Tensor-valued diffusion encoding employs gradient waveforms that enable unique sensitivity to microstructural features of tissue, but the interpretation of signal and parameters may be confounded by diffusion-time dependence. We introduce a framework for restriction-weighted q-space trajectory imaging (ResQ) that incorporates diffusion-time effects via the restriction-weighting tensor, and we evaluate it in a longitudinal study of prostate cancer xenografts treated by external radiotherapy. We proposed a novel gradient waveform design for tensor-valued encoding with controlled restriction weighting and applied a set of four waveforms at a 9.4 T preclinical MRI system. Mice were inoculated with human prostate cancer cells (LNCaP) and assigned to groups that were untreated controls or treated by external beam irradiation. ResQ produced parameters that describe the diffusion process in terms of the mean diffusivity (D), isotropic diffusional variance (V

Indexed as

Diffusion Magnetic Resonance ImagingProstatic NeoplasmsAnimalsAnisotropyCell Line, TumorHeterograftsHumansMaleMiceTime Factors

Identifiers

PMID42366513
PMCPMC13311205

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.