ArticlePest management science2026
Nematicidal activity of multi-halogenated indoles against Caenorhabditis elegans.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
backgroundPlant-parasitic nematodes (PPN) cause annual crop losses exceeding US$157 billion worldwide, and escalating resistance to conventional nematicides demands novel chemical scaffolds. Although indole derivatives exhibit broad-spectrum bioactivity, the nematicidal potential of multi-halogenated indoles remains underexplored. This study evaluates 50 halogen-substituted indoles for nematicidal activity using Caenorhabditis elegans as a proxy nematode model, with mechanistic investigation through phenotypic, in vitro, and in silico approaches.
resultsFifty multi-halogenated indoles were screened for nematicidal activity. Particularly, 4,5-dichloroindole (45DCI), 4,6-dibromoindole (46DBI), and 4,6-dichloroindole (46DCI) displayed rapid and potent nematicidal effects in C. elegans, with an LC
conclusionDi-halogenated indoles, particularly C4/C6-substituted derivatives, exhibit potent multi-stage nematicidal activity in the free-living model nematode C. elegans, disrupting locomotion, development, and stress tolerance through ROS induction. While molecular docking indicates a potential mechanism via GST-5 inhibition, experimental validation is required to conclusively establish this mode of action. These findings provide preliminary evidence supporting further evaluation of di-halogenated indoles against PPN species. © 2026 Society of Chemical Industry.
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