Evidence map›Paper›PMID 42366414›Full record

ArticleCell communication and signaling : CCS2026

A bispecific-aptamer TSHR-CD80-1 treats thyroid eye disease by inhibiting CD8

Jiamin Cao, Zhaochangci Chen, Lemeng Feng, Bingyu Xie, Yao Tan, Wei Xiong, Feng Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiamin CaoDepartment of Ophthalmology, Third Xiangya Hospital of Central South University, Changsha City, China.
Zhaochangci ChenDepartment of Ophthalmology, Third Xiangya Hospital of Central South University, Changsha City, China.
Lemeng FengDepartment of Ophthalmology, Third Xiangya Hospital of Central South University, Changsha City, China.
Bingyu XieDepartment of Ophthalmology, Third Xiangya Hospital of Central South University, Changsha City, China.
Yao TanDepartment of Ophthalmology, Third Xiangya Hospital of Central South University, Changsha City, China.
Wei XiongDepartment of Ophthalmology, Third Xiangya Hospital of Central South University, Changsha City, China.
Feng ZhangDepartment of Ophthalmology, Third Xiangya Hospital of Central South University, Changsha City, China. fengz2022@csu.edu.cn.

Funding

National Natural Science Foundation of China 82371104
6 · The paper itself

Abstract

Thyroid eye disease (TED), an autoimmune disorder, involves critical interactions among immune cells that drive disease progression. However, the underlying mechanisms and their therapeutic potential remain unclear. This study profiled leukocyte composition in the peripheral blood of TED patients, revealing an elevated proportion of CD8

Indexed as

Aptamers, NucleotideCD8-Positive T-LymphocytesCell CommunicationFibroblastsGraves OphthalmopathyReceptors, ThyrotropinAnimalsFemaleHumansMaleMiceAptamers, NucleotideReceptors, ThyrotropinCD80CD8+ T cellsNucleic acid aptamerOrbital fibroblastsThyroid eye diseaseTSHR

Identifiers

PMID42366414
PMCPMC13576272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.