Evidence map›Paper›PMID 42366382›Full record

ReviewStem cell research & therapy2026

The impact of T cell exhaustion in hematopoietic stem cell transplantation.

Yue Li, Huidong Guo, Yikai Zhang, Jie Chen, Liye Zhong, Xiaojun Huang, Yangqiu Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yue LiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory for Regenerative Medicine, Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Huidong GuoPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China.
Yikai ZhangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory for Regenerative Medicine, Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Jie ChenDepartment of Hematology, First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.
Liye ZhongDepartment of Hematology, First Affiliated Hospital of Jinan University, Guangzhou, 510632, China.
Xiaojun HuangPeking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Cell and Gene Therapy for Hematologic Malignancies, Peking University, Beijing, China. xjhrm@medmail.com.cn.
Yangqiu LiState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Key Laboratory for Regenerative Medicine, Ministry of Education, Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China. yangqiuli@hotmail.com.

Funding

Fundamental Research Funds for the Central Universities 21623121Fundamental Research Funds for the Central Universities 21625219National Natural Science Foundation of China 82293630National Natural Science Foundation of China 82293632National Natural Science Foundation of China 82400259Science and Technology Project in Guangzhou 202102070001
6 · The paper itself

Abstract

T cell exhaustion is a hallmark of failure to control cancer and chronic infection. In hematological malignancies, T cell exhaustion not only relates to disease progression but also impacts the outcome of hematopoietic stem cell transplantation (HSCT), which may be due to a low graft-versus-leukemia (GVL) effect and a low anti-virus infection capacity. However, a deeper mechanistic understanding of the impact of T cell exhaustion in HSCT remains to be characterized. In this review, we summarize the characteristics of T cell exhaustion, functional alterations in T cells post-transplantation, the role of T cell exhaustion in post-transplant complications, and related therapeutic strategies.

Indexed as

Hematologic NeoplasmsHematopoietic Stem Cell TransplantationT-Cell ExhaustionT-LymphocytesAnimalsGraft vs Host DiseaseGraft vs Leukemia EffectHumansClinical outcomeGraft-versus-host disease (GVHD)Graft-versus-leukemia (GVL)Hematopoietic stem cell transplantation (HSCT)Immune checkpointsT cell exhaustion

Identifiers

PMID42366382
PMCPMC13579798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.