ReviewThe international journal of cardiovascular imaging2026
Photon-counting detector CT in cardiovascular imaging: technical advances, clinical applications, and future perspectives.
Review in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
This review comprehensively reviews the technical advances, cardiovascular clinical applications, current limitations, and future perspectives of photon-counting detector CT (PCD-CT) to provide evidence-based guidance for clinical imagers and researchers. A structured literature search was conducted in PubMed, Web of Science, and Embase (January 2015 to March 2025) using the terms 'photon-counting detector CT', 'cardiovascular imaging', 'coronary artery disease', 'spectral CT', and 'congenital heart disease', combined with Boolean operators. Eligible peer-reviewed original studies and authoritative technical reports published in English were screened independently by two reviewers and included by consensus. As a narrative review, no formal risk-of-bias scoring or quantitative meta-analysis was performed. PCD-CT achieves an in-plane spatial resolution of approximately 125 μm (versus ~ 208 μm for EID-CT) and reduces radiation dose by 30-54%. In a 68-patient prospective study of heavily calcified high-risk patients, ultra-high-resolution (UHR) PCD-CT angiography demonstrated a per-vessel sensitivity of 96% and a negative predictive value of 97%, and in a separate cohort 100% sensitivity with 100% negative predictive value for coronary stent patency (44 stents in 18 patients). Myocardial extracellular volume derived from PCD-CT correlates strongly with cardiac MRI (r = 0.82-0.91). In congenital heart disease, PCD-CT reduces radiation dose by more than 40% while improving diagnostic image quality from 77% to 97%. Contrast medium volume reductions of 25% or more are validated across aortic and pediatric indications. PCD-CT offers substantial technical advances across cardiovascular imaging. Large-scale, multicenter, prospective trials are needed to establish patient-level outcome benefits and support guideline integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.