Evidence map›Paper›PMID 42366297›Full record

ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Neuropsychological assessment in adult epilepsy: rationale, test selection, and clinical integration across non-surgical care in Italian patients.

Francesco Tomaiuolo, Carmelo Mario Vicario, Davide Cardile, Serena Campana, Rocco Salvatore Calabrò, Francesco Corallo, Angelo Labate

Abstract readReview
In one paragraph

Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francesco TomaiuoloDepartment of Clinical and Experimental Medicine, University Hospital of Messina, University of Messina, Messina, 98125, Italy.
Carmelo Mario VicarioDepartment of Cognitive Sciences, Psychology, Education and Cultural Studies, University of Messina, Messina, 98125, Italy.
Davide CardileIRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy. davide.cardile@irccsme.it.ORCID http://orcid.org/0000-0003-2052-0970
Serena CampanaNeurorehabilitation Unit, Auxilium Vitae Volterra, Via Borgo San Lazzero 5, Volterra, 56048, Italy.
Rocco Salvatore CalabròIRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Francesco CoralloIRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy.
Angelo LabateNeurology Clinic, University of Palermo, Palermo, Italy.

Funding

Ministero della Salute Ministero della Salute
6 · The paper itself

Abstract

To provide a practical framework for neuropsychological assessment in adult epilepsy, specifying what each measure evaluates and how results can support clinical decisions regarding epileptic patients. This work is a clinically oriented narrative review and expert proposal for non-surgical adult epilepsy care in Italian settings. Test selection was guided by domains repeatedly emphasized in epilepsy neuropsychology, by their practical relevance to routine clinical decision-making, by compatibility with major international recommendations, and by the availability of Italian adaptations or normative data. For each test, we describe the primary construct assessed and the specific epilepsy-related clinical question it may help address. Structured cognitive exams can be sensitive to lateralization and localization, medication-related cognitive effects, and comorbid mood and anxiety symptoms. When integrated with electroencephalography and structural imaging, these profiles support clinical interpretation and guide counseling. Serial assessment can also inform medical management, rehabilitation planning, and quality-of-life interventions. The expanded framework clarifies which patients should be referred for assessment, why epilepsy must be conceptualized as a heterogeneous group of syndromes and network disorders, where neuropsychological data may support but not replace differential diagnosis, and how current ILAE recommendations contextualize the proposed battery. Neuropsychological assessment is a core component of comprehensive epilepsy care, but its clinical value is greatest when the battery is tailored to the referral question, syndrome, disease stage, treatment context, and patient priorities. The proposed battery should be read as a structured, adaptable framework for routine adult non-surgical practice, rather than as a rigid battery to be applied uniformly across patients.

Indexed as

EpilepsyNeuropsychological TestsAdultHumansItalyAdult epilepsyClinical managementCognitionEpilepsyNeuropsychological assessmentPatient-reported outcomes

Identifiers

PMID42366297
PMCPMC13310820

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.