Evidence map›Paper›PMID 42366275›Full record

ArticleCommunications biology2026

Gα

Lucrezia Zanetti, Luca Franchini, Shirsha Saha, Yini Liao, Brian S Muntean, Cesare Orlandi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

  • Update of
    G2025
5 · Who and what money

Authors and funding

6 authors.

Lucrezia Zanetti *Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0009-0003-0139-3862
Luca Franchini *Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-2845-2223
Shirsha SahaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-0036-4969
Yini LiaoDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Brian S MunteanDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0001-9090-2929
Cesare OrlandiDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY, USA. cesare_orlandi@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-4992-9350

Funding

Discovery of synthetic and endogenous ligands for orphan GPCR GPR156R01DC022104 · NIDCD · UNIVERSITY OF ROCHESTER · PI Cesare Orlandi · 2024 to 2026
$2.0M
Role of KCTD proteins in striatal signalingR01NS129554 · NINDS · AUGUSTA UNIVERSITY · PI Brian S Muntean · 2023 to 2026
$1.5M
NIDCD NIH HHS R01 DC022104NINDS NIH HHS R01 NS129554U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01 NS129554U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01 DC022104
6 · The paper itself

Abstract

Dopamine receptors are G protein coupled receptors (GPCRs) that serve as key targets for FDA-approved drugs to treat various neuropsychiatric disorders. Notably, ~11% of all marketed GPCR-targeting drugs act on dopamine receptors. Five GPCRs mediate the effects of endogenous dopamine and compounds used to treat Parkinson's disease, schizophrenia, and other conditions. However, on-target side effects associated with these medications highlight the need to analyze dopamine receptor signaling to design safer, more effective therapeutics. Here, we characterize the G protein coupling of dopamine D2-like receptors and observe the striking inability of D3R to engage with Gα

Indexed as

GTP-Binding Protein alpha Subunits, Gi-GoReceptors, Dopamine D3AnimalsHEK293 CellsHumansReceptors, Dopamine D2Signal TransductionGTP-Binding Protein alpha Subunits, Gi-GoReceptors, Dopamine D2Receptors, Dopamine D3

Identifiers

PMID42366275
PMCPMC13677679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.