ReviewCell death discovery2026
Reprogramming in delipidated adipocytes: metabolism, regulation and progress.
Review in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Through specific induction protocols in vitro or under physiological or pathological conditions in vivo, mature adipocytes can be converted into mesenchymal stem cells, challenging our traditional understanding of mature adipocyte identity and cell fate determination. Given that dedifferentiated adipocytes are a rich source of stem cells in the human body, they hold great potential for applications in regenerative medicine. This review discusses the process of lipid droplet depletion and the stage-specific metabolic remodeling of intracellular substances-including triglycerides and free fatty acids, energy-related metabolites (ATP, NAD⁺/NADH, acetyl-CoA), as well as the alterations in key proteins, organelle remodeling, and epigenetic modifications. These insights provide a deeper understanding of adipocyte identity and the molecular mechanisms underlying the transition between different adipocyte differentiation stages. The review also highlights advanced techniques in the field, including adipocyte lineage-tracing models and single-cell RNA sequencing, enhancing the accuracy and precision of research while enabling the capture of dynamic changes within cells. These advancements offer a more comprehensive approach to studying dedifferentiated adipocytes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.